CHICAGO ILLINOIS – Families searching for the per

first_imgCHICAGO, ILLINOIS – Families searching for the perfect spring break vacation to unique locales coupled with once-in-a-lifetime experiences are in luck. This spring break, Kipling & Clark, the purveyors of private luxury travel to Asia, is inviting families to pack up the kids and head to Japan for the nine-day family tour of Tokyo, Takayama, Kyoto and Nara. This exclusive five-star Asian holiday is filled with family-friendly activities and all-access to cultural experiences not always available to the traveling public. From catching a private sumo wrestling practice and dressing up like a Geisha for an intimate dinner party to visiting ancient Kyoto shrines and temples and taking in the gorgeous April cherry blossoms, this spring break trip to Japan is sure to turn moments into memories.“Our philosophy is to deliver an experience that is educational, cultural and memorable, while exceeding all expectations,” explained Kipling & Clark Founder Randy Lynch. “Therefore, we designed this private Japanese spring break package to enrich, inspire and educate every member of the family and include exceptional services, amenities and much more.”The spring break family tour includes five-star luxury accommodations and air transportation, expert ground staff hand selected by Kipling & Clark. All of the above arrangements are accompanied by private guide and driver.www.kiplingandclark.com/last_img read more

Microscope captures intricate images of glowing brains at record speed

first_img Thanks to sophisticated computational tools that stitch thousands of 3D sections together, the researchers showed they could capture large areas of brain and then zoom in at high resolution. The approach should make it easier to study how circuits of interacting neurons across the brain drive certain behaviors, and how that circuitry varies across lots of individuals, between sexes, or over the course of development. Gao et al./Science 2019 Gao et al./Science 2019 Suppose you’d like to take a close look at a fly brain—an extremely close look. With a new technique called expansion microscopy, scientists have been doing just that: labeling neurons of interest and tracing their thinnest tendrils to chart their connections. But the process, which infuses a piece of brain tissue with a gel that swells up to enlarge the details, dramatically increases the time it takes to image that tissue. And as a microscope beam images parts of this thick sample from top to bottom, it can “burn out” the fluorescent tags attached to proteins that help identify the neurons, making deeper parts of the sample completely dark.In a new study, researchers present a solution: combining that expansion process with an instrument called a lattice light-sheet microscope, which sweeps an ultrathin sheet of light through the sample. Because this microscope can linger longer on any area with less intense light than other microscopes, the fluorescence is less likely to burn out and obscure parts of the image—which means that sharp, intricate details, such as the spines on mouse neurons (shown in green, above) can emerge. And by capturing a whole plane at once instead of a set of points, this microscope worked through an entire fly brain (below) in 62.5 hours, roughly seven times faster than the fastest microscope used in such high-resolution imaging to date, the team reports today in Science.center_img By Kelly ServickJan. 17, 2019 , 2:00 PM Microscope captures intricate images of glowing brains at record speedlast_img read more